Approach to a Patient with Connective Tissue Disease
Identifieur interne : 001743 ( Main/Exploration ); précédent : 001742; suivant : 001744Approach to a Patient with Connective Tissue Disease
Auteurs : T. Sathish Kumar [Inde] ; Amita Aggarwal [Inde]Source :
- The Indian Journal of Pediatrics [ 0019-5456 ] ; 2010-10-01.
English descriptors
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Abstract
Abstract: Connective tissue disease (CTDs), though rare in childhood, are an important cause of morbidity. Most of them involve multiple organ systems and are associated with presence of autoantibodies. Systemic lupus eryethematosus (SLE) is the most common CTD, the others being Juvenile dermatomyositis, systemic sclerosis, mixed connective disease and Sjogren syndrome. The clinical presentation of CTD in childhood can range from an acute severe illness mimicking a serious infection, to an insidious onset of disease with gradual accumulation of symptoms and signs over wks to months. The presence of multi-system involvement, evidence of inflammation and lack of any obvious cause should alert a clinician to the possibility of CTD. Diagnosis is usually clinical and features like malar rash, Raynaud’s phenomenon, Gottron’s rash, photosensitivity, oral ulcers suggest a possibility of CTD. Presence of autoantibodies like anti-nuclear antibodies, anti-dsDNA etc. provide supportive evidence to a diagnosis of CTD. Most CTDs are treated with immunosuppressive drugs with good success. Early recognition and prompt treatment results in excellent outcome
Url:
DOI: 10.1007/s12098-010-0207-x
Affiliations:
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Sathish Kumar</name><affiliation wicri:level="1"><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Child Health, Christian Medical College, Vellore</wicri:regionArea><wicri:noRegion>Vellore</wicri:noRegion></affiliation></author><author><name sortKey="Aggarwal, Amita" sort="Aggarwal, Amita" uniqKey="Aggarwal A" first="Amita" last="Aggarwal">Amita Aggarwal</name><affiliation wicri:level="1"><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow</wicri:regionArea><wicri:noRegion>Lucknow</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Inde</country></affiliation></author></analytic><monogr></monogr><series><title level="j">The Indian Journal of Pediatrics</title><title level="j" type="abbrev">Indian J Pediatr</title><idno type="ISSN">0019-5456</idno><idno type="eISSN">0973-7693</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>India</pubPlace><date type="published" when="2010-10-01">2010-10-01</date><biblScope unit="volume">77</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1157">1157</biblScope><biblScope unit="page" to="1164">1164</biblScope></imprint><idno type="ISSN">0019-5456</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0019-5456</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Autoantibodies</term><term>Autoimmune diseases</term><term>Connective tissue disease</term><term>Systemic lupus erythematosus</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Connective tissue disease (CTDs), though rare in childhood, are an important cause of morbidity. Most of them involve multiple organ systems and are associated with presence of autoantibodies. Systemic lupus eryethematosus (SLE) is the most common CTD, the others being Juvenile dermatomyositis, systemic sclerosis, mixed connective disease and Sjogren syndrome. The clinical presentation of CTD in childhood can range from an acute severe illness mimicking a serious infection, to an insidious onset of disease with gradual accumulation of symptoms and signs over wks to months. The presence of multi-system involvement, evidence of inflammation and lack of any obvious cause should alert a clinician to the possibility of CTD. Diagnosis is usually clinical and features like malar rash, Raynaud’s phenomenon, Gottron’s rash, photosensitivity, oral ulcers suggest a possibility of CTD. Presence of autoantibodies like anti-nuclear antibodies, anti-dsDNA etc. provide supportive evidence to a diagnosis of CTD. Most CTDs are treated with immunosuppressive drugs with good success. Early recognition and prompt treatment results in excellent outcome</div></front></TEI><affiliations><list><country><li>Inde</li></country></list><tree><country name="Inde"><noRegion><name sortKey="Kumar, T Sathish" sort="Kumar, T Sathish" uniqKey="Kumar T" first="T. Sathish" last="Kumar">T. Sathish Kumar</name></noRegion><name sortKey="Aggarwal, Amita" sort="Aggarwal, Amita" uniqKey="Aggarwal A" first="Amita" last="Aggarwal">Amita Aggarwal</name><name sortKey="Aggarwal, Amita" sort="Aggarwal, Amita" uniqKey="Aggarwal A" first="Amita" last="Aggarwal">Amita Aggarwal</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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